Rivera-Denizard, Omayra

Publication Search Results

Now showing 1 - 1 of 1

Biocompatibility studies of human fetal osteoblast cells cultured on gamma titanium alumide
(2005) Rivera-Denizard, Omayra; Diffoot-Carlo, Nanette; College of Arts and Sciences - Sciences; Navas, Vivian; Sundaram, Paul A.; Department of Biology; Rios, Robert
There is a continuous search of new implant materials with better biocompatibility and physiological properties than the current commercially pure Ti and Ti-6Al-4V alloys. Gamma titanium aluminide (γTiAl) appears to have excellent potential for bone repair and replacement. The response to γTiAl implant is expected to be similar or better than those of Ti-6Al-4V. Human fetal osteoblast cells were cultured on the surface of γTiAl and Ti-6Al-4V discs with variable surface roughness for both SEM and immunofluorescent analysis to detect the presence of collagen type I and osteonectin, proteins of the bone extracellular matrix. Results show that cell growth and attachment on γTiAl was normal compared to that of Ti-6Al-4V, suggesting that γTiAl is not toxic to osteoblasts. Normal growth and the presence of collagen type I and osteonectin was observed on γTiAl and Ti-6Al-4V. The results obtained suggest γTiAl is biocompatible with the osteoblasts.