Aguilar García, Xavier J.

Profile Picture

Filters

20231
Reset filters

Settings

Citations

Publication Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    Publication
    Study of breast and colorectal cancers in females through biooptimatics
    (2023-12-09) Aguilar García, Xavier J.; Cabrera Ríos, Mauricio; College of Engineering; Isaza Brando, Clara I.; Latorre Esteves, Magda M.; Bonet Olivencia, Samuel A.; Department of Industrial Engineering; Parés Parés, C. Patricia
    Cancer constitutes a significant public health issue, being the second leading cause of death worldwide among non-communicable diseases. Breast Cancer (BC) and Colorectal Cancer (CRC) are two of the most common cancers affecting women globally. Several organizations have taken on the task of studying women's health, especially in the field of oncology. The purpose of this research is to explore the genetic similarities between BC and CRC and determine the potential identification of biomarkers through the simultaneous analysis of both types of cancer. A meta-analysis approach is proposed, involving the selection of microarray datasets for both cancers. Ten datasets from the Gene Expression Omnibus (GEO) will be analyzed using mathematical optimization tools, particularly Multiple Criteria Optimization (MCO) and Minimum Spanning Tree (MST). This will help identify promising biomarker genes for both types of cancer. The resulting genes will be further investigated in the literature and existing databases to determine their roles in cancer signaling pathways. The results are encouraging, with 16 out of 18 identified genes reported in the literature as associated with BC and CRC. This suggests the possibility of identifying differentially expressed genes as potential biomarkers for various cancers, including BC and CRC in women. These findings could contribute to a better systemic understanding of cancer that primarily affects women.