Seda-Barrios, Mariana I.

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Cyclic voltammetry of DNA bases adsorbed onto polycrystalline gold surface; effect of the adsorbates on the carboplatin oxidation signal
(2005) Seda-Barrios, Mariana I.; Vega Olivencia, Carmen A.; College of Arts and Sciencies - Sciences; Román, Félix A.; Meléndez, Enrique; Department of Chemistry; Santos, Jeannette
There is an increasing interest in the creation of modified surfaces with properties that differ from the corresponding bare surfaces. A variety of modified metal surfaces can be developed for several purposes, including surface protection and corrosion inhibition. In order to study the effect of a modified gold surface over the electroactivity of a particular species, carboplatin was chosen as a model electroactive species. The present work was aimed to determine the effect of adsorbed DNA bases on the electrode-mediated oxidation of aqueous carboplatin at physiological conditions. Hydrolyzed carboplatin is an electroactive species capable of undergoing electrocatalytic oxidation over a clean polycrystalline gold surface. Cyclic voltammetry experiments revealed that adsorbed purine bases on gold are good inhibitors of the carboplatin electrocatalytic oxidation. Results will be presented for the interfacial behavior of the four DNA bases over polycrystalline gold surfaces. Recommendations will be given in order to obtain new insights for future work in the field of surface electrochemistry.