López Reyes, Jamir E.

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Low density lipoprotein receptor as a possible primary receptor for Dengue virus serotype 2
(2022-04-18) López Reyes, Jamir E.; Diffoot-Carlo, Nanette; College of Arts and Sciences - Sciences; Rodríguez Minguela, Carlos M.; Montalvo-Rodríguez, Rafael R.; Department of Biology; Curbelo-Rodríguez, Jaime E.
Viral diseases are currently one of the main public health threats worldwide Recently, Arboviruses have been in the center of modern epidemics, in the Hispanic Caribbean and South America. Currently the most prevalent Arboviral Disease is Dengue Fever. Identification of virus candidate receptors associated with the host cell infection process, is of great importance. This will contribute to the characterization of the primary virus receptor or receptors. The hypothesis of this study is that the Low Density Lipoprotein receptor (LDL-R) could represent a primary receptor for DENV-2. Based on the results of this research; we confirm that the Human LDL Receptor should be considered a possible primary receptor for DENV-2 based on its capacity to bind with the viral Envelope protein (E protein) and its impact on cell infection.