Diazgranados-Jiménez, Jorge A.

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Design of an intravenous drug delivery device
(2004-05) Diazgranados-Jiménez, Jorge A.; Dooner, David B.; College of Engineering; Sundaram, Paul A.; Gutiérrez, Gustavo; Department of Mechanical Engineering; Torres, Madeline
The use of intravenous implanted devices to deliver controlled drug dosage for the treatment of certain health problems is becoming more common as an alternative to regular injection procedures. This work proposes a conceptual design for a self-regulated device controlled by blood pressure and heart rate that can be implanted inside an artery and supply the controlled dosage of a specific drug in the event of a hypertension episode. The device is designed to discharge an established dosage of drug into the blood stream. The system of differential equations that describes the mathematical model of the selected device was simulated through the use of control block diagrams in a dynamic graphical interface software environment. The simulation of the device operation allowed for the graphical visualization of the drug delivery, aiding in the determination of device dimensions and parameters necessary to achieve a desired drug dosage for a given hypertension duration.