Genetic commonalities of autism spectrum disorder and schizophrenia

dc.contributor.advisor Cabrera-Ríos, Mauricio Font-Valentín, Amil A. College of Engineering en_US
dc.contributor.committee Méndez, Mayra
dc.contributor.committee Seguel, Jaime
dc.contributor.department Department of Industrial Engineering en_US
dc.contributor.representative Ortíz, Gloribell 2019-04-15T12:18:28Z 2019-04-15T12:18:28Z 2019-01-23
dc.description.abstract The characterization of a disease through the detection of differentially expressed genes is of interest for early detection, diagnosis, prognosis, and prediction. Autism Spectrum Disorder (ASD) and Schizophrenia (SCZ) have been correlated in literature for sharing similar symptoms and behaviors, however, not at the genetic level. This work aims to correlate both conditions through the analysis of microarray datasets. Multiple Criteria Optimization was used to find the most significant gene expression changes common to both conditions. Thirty-six genes resulted from this first step. Subsequently, the most correlated structures were identified through the Traveling Salesman Problem and the Minimum Spanning Tree. Mathematical optimization, as a driver for gene selection and structuring, defines an analysis point of view advocated by our group that is different to biostatistics and bioinformatics. ASD and SCZ are analyzed simultaneously for the first time in this work owing to the capabilities of our group’s strategy. en_US
dc.description.graduationSemester Spring en_US
dc.description.graduationYear 2019 en_US
dc.language.iso en en_US
dc.rights.holder (c) 2019 Amil A. Font Valentín en_US
dc.rights.license All rights reserved en_US
dc.subject Autism Spectrum Disorder en_US
dc.subject Schizophrenia en_US
dc.subject Commonalities en_US
dc.subject Genes en_US
dc.subject Optimization en_US
dc.subject.lcsh DNA microarrays en_US
dc.subject.lcsh Mathematical optimization en_US
dc.subject.lcsh Autism Spectrum Disorder en_US
dc.subject.lcsh Schizophrenia en_US
dc.subject.lcsh Diseases -- Causes and theories of causation en_US
dc.title Genetic commonalities of autism spectrum disorder and schizophrenia en_US
dc.type Thesis en_US
dspace.entity.type Publication Industrial Engineering en_US M.S. en_US
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