Development of calibration models within a closed feed frame to determine drug concentration using near infrared spectroscopy

dc.contributor.advisor Romañach, Rodolfo J. Movilla Meza, Nathaly A. College of Arts and Sciences - Sciences en_US
dc.contributor.committee Méndez Román, Rafael
dc.contributor.committee López Moreno, Martha
dc.contributor.department Department of Chemistry en_US
dc.contributor.representative Resto Irizarry, Pedro 2021-12-21T14:02:20Z 2021-12-21T14:02:20Z 2021-12-08
dc.description.abstract The closed feed frame (without the die disc) was evaluated as an option to reduce the amount of material for the development near-infrared spectroscopic calibration models. Lubricated and unlubricated blends were prepared with concentrations between 4.2 -7.8% w/w of caffeine. All the blends recirculated inside the closed feed frame while NIR spectra were obtained. The physical characterization of the blends was made and it confirmed that the properties of the powder blends were not altered during the recirculation inside the closed feed frame. The calibration models developed using lubricated blends resulted in a good performance predicting three closed feed frame blends and three open feed frame blends. The best calibration model developed with the unlubricated blends presents higher predicted errors compared with the lubricated blends-model. The material required were reduced by 95% without negatively affecting the performance of the calibration model. en_US
dc.description.abstract En este estudio se evaluó el uso del marco de alimentación cerrado como una opción para reducir la cantidad de material para el desarrollo de modelos de calibración utilizando espectroscopía de infrarrojo cercano. Se prepararon mezclas lubricadas y no lubricadas con concentraciones entre 4.2-7.8% p/p de cafeína. Para la adquisición espectral, todas las mezclas recircularon dentro del marco de alimentación cerrado. Se realizó la caracterización física de ambos tipos de mezclas y se confirmó que las propiedades de las mezclas en polvo no se alteraron durante la recirculación dentro del marco de alimentación cerrado. Los modelos de calibración desarrollados con mezclas lubricadas dieron como resultado un buen rendimiento al predecir tanto las mezclas que recircularon dentro del marco de alimentación cerrado como las que fluyeron en un marco de alimentación abierto. Por otra parte, el mejor modelo desarrollado con las mezclas sin lubricar presentó mayores errores predictivos que con las mezclas lubricadas. La cantidad de material utilizado se redujo en un 95% sin afectar negativamente la capacidad predictiva del modelo de calibración. en_US
dc.description.graduationSemester Spring en_US
dc.description.graduationYear 2022 en_US
dc.description.sponsorship Investigation subsidized with funds from the Puerto Rico Science Technology and Research Trust [Grant number 2020-00116]. en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.holder (c) 2021 Nathaly A. Movilla Meza en_US
dc.rights.uri *
dc.subject Feed frame en_US
dc.subject Near-infrared spectroscopy en_US
dc.subject Calibration models en_US
dc.subject Blend uniformity en_US
dc.subject Lubrication en_US
dc.subject.lcsh Near infrared spectroscopy en_US
dc.subject.lcsh Spectrometer - Calibration - Lubrication en_US
dc.subject.lcsh Feed mechanisms en_US
dc.title Development of calibration models within a closed feed frame to determine drug concentration using near infrared spectroscopy en_US
dc.type Thesis en_US
dspace.entity.type Publication Chemistry en_US M.S. en_US
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
2.17 MB
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
2.26 KB
Item-specific license agreed upon to submission