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dc.contributor.advisorDíaz-Rivera, Rubén E.
dc.contributor.authorGonzález-Jiménez, Stephanie E.
dc.description.abstractToday, microfluidic devices have gained popularity in the areas of biology, chemistry, biomedical, bio-engineering, etc., as these can perform the functions of a complete laboratory in a very small space. This project aims to design, create and test a microfluidic device capable of effectively entrapping many particles (15µm dia.) individually; in order to later use this device to isolate and study cells. First, to achieve this goal, the controversial slipcondition at the micro-scale was studied and its effects in the design of polydimethylsiloxane (PDMS) micro-devices were determined. Next, using the Hardy-Cross Method (HCM) for a network of channels, the maximum possible number of traps in series that guaranteed an effective trapping of particles was investigated. Finally, the determined series arrangement was expanded to a parallel arrangement. After these considerations, the main objective was achieved and a new device was designed with a total of 800 trap-sites.en_US
dc.description.sponsorshipRISE-2BEST Program, Grant NIH-R25GM088023en_US
dc.subjectMicrofluidic devicesen_US
dc.subject.lcshMicrofluidic devices.en_US
dc.titleDesign of high-throughput microfluidic device for individual entrapment of micro-particlesen_US
dc.rights.licenseAll rights reserveden_US
dc.rights.holder(c) 2015 Stephanie E. González Jiménezen_US
dc.contributor.committeeValentín, Ricky
dc.contributor.committeeQuintero, Pedro
dc.contributor.representativeBaigés, Iván Engineeringen_US
dc.contributor.collegeCollege of Engineeringen_US
dc.contributor.departmentDepartment of Mechanical Engineeringen_US

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    Items included under this collection are theses, dissertations, and project reports submitted as a requirement for completing a graduate degree at UPR-Mayagüez.

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