The replication of autonomous parvovirus LuIII and its encapsidation
pattern have not been fully explained. Two genomic clones of LuIII, pBLu(+) and
pBLu(-), were constructed. These clones were used to produce the (+) ...
Parvoviruses are small, non-enveloped, icosahedral viruses that contain a
linear, single-stranded DNA genome of approximately 5000 bp. Parvovirus LuIII is an
autonomous parvovirus that shares up to 80% of sequence homology ...
The synthesis of minus strand by parvovirus LuIII requires replication from the
left palindrome of the plus strand DNA. An origin of replication yet to be identified must
be present at the right end of the minus strand, ...
Studies to elucidate the mechanism of parvoviral replication are ongoing
due to their potential as transient vectors for human gene therapy. Parvovirus
LuIII, a single stranded DNA virus, has short double-stranded hairpin ...
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