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Synthesis, characterization, cytotoxic studies, and biosensor development of ferrocenecarboxylate complexes
(2013)
The application of ferrocene chemistry in biosensing and as potential anti-cancer drug is presented in this research work. A series of modified ferrocenes with a variety of groups were synthesized and their structures ...
Synthesis, chemical and biochemical characterization of TiIV and VIV complexes with anti-tumor activity
(2010)
At the present time in which the metallocene dihalides have shown to possess antitumoral activity, scientists of all around the world have been working with the synthesis and structural modifications to improve their ...
Síntesis y estudios mecanísticos de complejos de molibdenoceno: Interacción de agentes metálicos anti-cáncer con el transporte de proteínas
(2012)
Nuevos complejos organometálicos fueron sintetizados, partiendo del dicloruro de molibdenoceno (Cp2MoCl2) y cuatro ligandos: L-Acido ascórbico(L-AA), 6-o-palmitoil-L- acido ascórbico (PAA), Etil maltol y D-penicilamina, ...
Synthesis, characterization, cytotoxic activity and biological interactions of tungstenocene (lv) derivatives
(2012)
The design of medicinal compounds for cancer therapy is still a challenge. Organometallics offer a wide variety of promising anticancer drug candidates but this field is largely unexplored. This study has been focused on ...
Structure-activity studies, role of transferrin, and gene expression profile of the cytotoxic activity of Ti(IV) complexes in colon adenocarcinoma
(2008-12)
Ligand modification on titanocene dichloride has the potential to produce soluble and stable complexes. As part of our research efforts in the area of titanium-based antitumor agents, we have investigated the cytotoxic ...
Synthesis, characterization, binding interactions with biomolecules and cytotoxic studies of molybdebocene complexes
(2009)
Bis-(cyclopentadienyl) molybdenum dichloride or molybdenocene dihalides, like other metallocenes dihalides, have shown antitumor properties in different human tumors. In contrast to titanocene dichloride, molybdenocene ...
Synthesis, characterization, cytotoxic studies of [(η5-C5H5)2Mo (thionucleobase/thionucleoside)]Cl complexes on cancer cell lines and their interaction with human serum albumin
(2010)
Molybdenocene dichloride like some other metallocene dihalides Cp2MX2 (M = Ti, V, Nb, Mo and X = halides) have shown high antiproliferative properties against a wide range of murine and human tumors. They also exhibit less ...
Supramolecular host-guest interactions of cyclodextrins and calixarenes with niobocene and vanadocene
(2010)
Cyclodextrins (CDs) and calixarenes act as a molecular host to a variety of guests: ions, metal complexes, polar and nonpolar organic molecules. These inclusion complexes have found pharmaceutical applications due to the ...
Synthesis, structural and cytotoxic studies of Metallocene-estrogen hormones conjugates for hormone dependent breast cancer application
(2019)
In this work we present the synthesis, characterization and application of a series of ferrocene-hormone conjugates at position 16 of the estrogen hormone moiety in order to develop a new class of metal-based therapeutic ...
New ferrocene chemotherapeutic drugs and early detection of breast cancer using a nanostructured gold biosensor
(2015)
Three new ferrocene complexes were synthesized with 4-(1H-pyrrol-1-yl)phenol group appended to the cyclopentadienyl (Cp) rings. These are: 1,1’-4-(1H-pyrrol-1- yl)phenyl ferrocenedicarboxylate, (‘Fc-(CO2-Ph-4-Py)2’), ...