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Thermodynamics governing binding of Homo sapiens centrin – Homo sapiens Sfi1p21 Complexes
(2012)
Centrin is a member of the EF-hand superfamily of calcium-binding proteins and has a molecular weight of ~20 kDa. In Homo sapiens, four centrin isoforms have been determined: centrin 1 (Hscen1), which is found in male germ ...
Exploring Centrin targets: KRR1, and the Centrin-SFI1p21 complex salt-bridge interaction
(2015)
Centrins are small calcium binding proteins and ubiquitous centrosome components. Centrins play a fundamental role in the structure and function of centrioles, basal bodies, primary cilia and the microtubule-organizing ...
Expression, isolation, purification, and characterization of recombinant human SFi1p1-2
(2013)
Homo sapiens Sfi1 (Hs Sfi1) is a 1242 amino acid protein containing 23 tandem binding sites for a calcium binding protein known as centrin. Hs Sfi1p₁₋₂ is an 8,592 Da peptide that corresponds to the first two centrin binding ...
The effects of centrin mutations on the affinity, stability, and structure of the Centrin-Sfi1p21 complex
(2018)
Centrin is a small, calcium binding protein part of the EF-hand superfamily. As one of the 347 eukaryotic signature proteins (ESPs), centrin has no bacterial or archaea homologue. Centrin is required for centriole duplication ...
Prp40: A novel centrin-binding protein
(2018)
Pre-mRNA processing protein 40 (Prp40) is a modular protein that has an essential role in the initiation step of pre-mRNA splicing. In Homo sapiens, Prp40 has two putative homologs: Prp40 homolog A (HsPrp40A) and homolog ...
Molecular biophysical characterization of a novel centrin-krr1 complex
(2018)
The nucleus is the natural compartment for DNA in eukaryotes. This compartment is also the setting for genetic mutations, nucleotide excision repair (NER), and ribosome biogenesis. The study of protein-protein interactions ...
Comparative protein analysis of two human isoforms Centrin 1 and Centrin 2
(2008)
Centrin is a calcium binding protein belonging to EF-hand superfamily that is found only in eukaryotic cells from yeast to humans. Three isoforms have been identified in humans two of which are presented in this work: human ...