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Near infrared spectroscopic transmission measurements for pharmaceutical powder mixtures and theory of sampling (TOS) applied in pharmaceutical industry quality control (Qc) practices
(2015)
This thesis presents two projects that involve the implementation of near infrared spectroscopy. NIR spectroscopy is a fast and non-destructive spectroscopy that in combination with multivariate analysis is a very useful ...
Development of calibration models for the in-line prediction of active pharmaceutical ingredient concentration in the range 0-100% W/W by near infrared and Raman spectroscopy
(2013)
The development of quantitative calibration models by near infrared (NIR) and Raman spectroscopy with the capability of predicting concentration in a wider range than the currently used approach will be described. Current ...
Development of a methodology to determine drug distribution in polymeric thin film formulations using hyperspectral image analysis
(2013)
This dissertation is focused on the development of analytical methods to determine drug distribution throughout polymeric films using hyperspectral image analysis. The NIR-CI and Raman mapping techniques have been used to ...
Development of a calibration model to determine drug concentration in pharmaceutical mixtures
(2011)
A robust calibration model was created using Near Infrared Spectroscopy (NIR) and by minimizing the correlation between the active pharmaceutical ingredient (API) and components in a pharmaceutical process. An experimental ...
A diffuse reflectance NIR spectroscopy method for determine drug concentration in pharmaceutical production tablets based on a PLS calibration model from manufactured tablets
(2018-05)
A diffuse reflectance near-infrared (NIR) spectroscopy method was developed to determine the active pharmacological ingredient (API) in pharmaceutical production tablets from batch and continuous manufacturing processes.
Tablets ...
Development of near infrared spectroscopy methodologies to provide physical information for pharmaceutical processes
(2013)
This research focused on increasing the number of applications and establishing methods to monitor physical properties from pharmaceutical materials using Near Infrared Spectroscopy (NIRS). NIRS in combination with chemometric ...
Development of calibration models within a closed feed frame to determine drug concentration using near infrared spectroscopy
(2021-12-08)
The closed feed frame (without the die disc) was evaluated as an option to reduce the amount of material for the development near-infrared spectroscopic calibration models. Lubricated and unlubricated blends were prepared ...
Development, validation, and implementation of NIR calibration models in a commercial continuous manufacturing process
(2017)
Near infrared spectroscopy is a very promising non-invasive technique since it allows the use of calibration models to monitor physical and chemical properties of raw materials, intermediate products (blend), and the end ...
Evaluation of sources of error in dynamic processes and material traceability in continuous pharmaceutical manufacturing through real-time spectroscopic analysis
(2021-05-05)
This dissertation focuses on the development of real-time spectroscopic methods to investigate the sources of variation in dynamic processes using variographic analysis and accomplish material traceability for continuous ...
Analysis of prediction errors in partial least squares calibration models using near infrared spectroscopy by three experimental systems
(2019-05-14)
This dissertation is focused on understanding the absorption and scattering effects of solid materials in the near infrared (NIR) spectral region and their impact on the prediction errors observed in NIR calibration models ...