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Dependence of active mode remote Ft-Ir sensing on angle of incidence, substrate type and analyte surface concentration
(2013-12)
A standoff detection scheme for a highly energetic material (HEM) and other threat chemicals deposited on substrates as contamination residues using Fourier transform infrared spectroscopy (FTIR) is described. The HEM used ...
Cleaning validation applications using Mid-Infrared quantum cascade laser spectroscopy
(2017)
According to the Recall Root Cause Research (RRCR), an initiative governed by the U.S. Food and Drug Administration (FDA), the contamination of pharmaceutical products is an alarming cause of public concern. During 2015, ...
Fourier transform infrared mapping to determine the distribution of active ingredients in pharmaceutical formulations
(2007)
A basic problem in pharmaceutical manufacturing is that a relatively simple formulation can produce widely varying therapeutic performance depending upon how the ingredients are distributed in the final matrix. Many methods ...
Remote infrared spectroscopy detection of highly energetic materials
(2015-12)
An Open-Path Standoff Detection System was designed using a telescope coupled to a EM27 Fourier Transform infrared spectrometer equipped with a mercury cadmium telluride (MCT) cryocooled detector. Samples of highly energetic ...
Development, validation, and implementation of NIR calibration models in a commercial continuous manufacturing process
(2017)
Near infrared spectroscopy is a very promising non-invasive technique since it allows the use of calibration models to monitor physical and chemical properties of raw materials, intermediate products (blend), and the end ...
Analysis of prediction errors in partial least squares calibration models using near infrared spectroscopy by three experimental systems
(2019-05-14)
This dissertation is focused on understanding the absorption and scattering effects of solid materials in the near infrared (NIR) spectral region and their impact on the prediction errors observed in NIR calibration models ...
Development of Blend Uniformity Determination Methodologies in Continuous Pharmaceutical Manufacturing Processes using Near- Infrared Spectroscopy
(2020-04-17)
Pharmaceutical companies are responsible for the development of their own blend uniformity specifications and guidelines to assure uniformity and homogeneity. Blend uniformity is a critical in the manufacturing of solid ...