Now showing items 1-6 of 6
A diffuse reflectance NIR spectroscopy method for determine drug concentration in pharmaceutical production tablets based on a PLS calibration model from manufactured tablets
A diffuse reflectance near-infrared (NIR) spectroscopy method was developed to determine the active pharmacological ingredient (API) in pharmaceutical production tablets from batch and continuous manufacturing processes. Tablets ...
Development of calibration models within a closed feed frame to determine drug concentration using near infrared spectroscopy
The closed feed frame (without the die disc) was evaluated as an option to reduce the amount of material for the development near-infrared spectroscopic calibration models. Lubricated and unlubricated blends were prepared ...
Development, validation, and implementation of NIR calibration models in a commercial continuous manufacturing process
Near infrared spectroscopy is a very promising non-invasive technique since it allows the use of calibration models to monitor physical and chemical properties of raw materials, intermediate products (blend), and the end ...
Evaluation of sources of error in dynamic processes and material traceability in continuous pharmaceutical manufacturing through real-time spectroscopic analysis
This dissertation focuses on the development of real-time spectroscopic methods to investigate the sources of variation in dynamic processes using variographic analysis and accomplish material traceability for continuous ...
Analysis of prediction errors in partial least squares calibration models using near infrared spectroscopy by three experimental systems
This dissertation is focused on understanding the absorption and scattering effects of solid materials in the near infrared (NIR) spectral region and their impact on the prediction errors observed in NIR calibration models ...
Development of Blend Uniformity Determination Methodologies in Continuous Pharmaceutical Manufacturing Processes using Near- Infrared Spectroscopy
Pharmaceutical companies are responsible for the development of their own blend uniformity specifications and guidelines to assure uniformity and homogeneity. Blend uniformity is a critical in the manufacturing of solid ...