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Near infrared spectroscopic transmission measurements for pharmaceutical powder mixtures and theory of sampling (TOS) applied in pharmaceutical industry quality control (Qc) practices
This thesis presents two projects that involve the implementation of near infrared spectroscopy. NIR spectroscopy is a fast and non-destructive spectroscopy that in combination with multivariate analysis is a very useful ...
Development of a calibration model to determine drug concentration in pharmaceutical mixtures
A robust calibration model was created using Near Infrared Spectroscopy (NIR) and by minimizing the correlation between the active pharmaceutical ingredient (API) and components in a pharmaceutical process. An experimental ...
Development of near infrared spectroscopy methodologies to provide physical information for pharmaceutical processes
This research focused on increasing the number of applications and establishing methods to monitor physical properties from pharmaceutical materials using Near Infrared Spectroscopy (NIRS). NIRS in combination with chemometric ...
Evaluation of sources of error in dynamic processes and material traceability in continuous pharmaceutical manufacturing through real-time spectroscopic analysis
This dissertation focuses on the development of real-time spectroscopic methods to investigate the sources of variation in dynamic processes using variographic analysis and accomplish material traceability for continuous ...