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Infectious capability of the plus (+) and minus (-) strands of parvovirus LUIII
The replication of autonomous parvovirus LuIII and its encapsidation pattern have not been fully explained. Two genomic clones of LuIII, pBLu(+) and pBLu(-), were constructed. These clones were used to produce the (+) ...
Replication of the 3' LUIII 3' subgenomic clone in human cells
Parvoviruses are small, non-enveloped, icosahedral viruses that contain a linear, single-stranded DNA genome of approximately 5000 bp. Parvovirus LuIII is an autonomous parvovirus that shares up to 80% of sequence homology ...
Study of an ARS-like function of map units 88-100 of parvovirus LUIII
The synthesis of minus strand by parvovirus LuIII requires replication from the left palindrome of the plus strand DNA. An origin of replication yet to be identified must be present at the right end of the minus strand, ...
Study of a possible replication origin function of map units 88-100 of parvovirus Luiii in HeLa cells
Studies to elucidate the mechanism of parvoviral replication are ongoing due to their potential as transient vectors for human gene therapy. Parvovirus LuIII, a single stranded DNA virus, has short double-stranded hairpin ...