Parvovirus B19 (B19) is a common human pathogen responsible for erythema infectiosum. Other disease manifestations include hydrops fetalis, transient aplastic crisis, arthropathy, and persistent infections in adults. B19 ...

The principal problem in current orthopedic implants is their loosening due to poor osseointegration. Many efforts have been made to modify the surface composition and topography of titanium alloy implants to attain improved ...

The corrosion resistance of gamma titanium aluminide (gamma-TiAl), a potential implant material, is increased in vitro by thermal oxidation. Although the biocompatibility of autoclaved gamma-TiAl was previously demonstrated, ...

Parvoviruses are currently being studied for use as possible genetic vectors in gene therapy. They are small, non-enveloped viruses of icosahedral structure, and possess a single-stranded DNA genome of approximately 5,000 ...

LuIII is a small, non-enveloped, icosahedral autonomous parvovirus that contains a small linear (5 kb) single stranded DNA genome and infects human cell lines lytically with no evidence of integration into cellular DNA. ...

The replication of autonomous parvovirus LuIII and its encapsidation pattern have not been fully explained. Two genomic clones of LuIII, pBLu(+) and pBLu(-), were constructed. These clones were used to produce the (+) ...

Parvoviruses are small, non-enveloped, icosahedral viruses that contain a linear, single-stranded DNA genome of approximately 5000 bp. Parvovirus LuIII is an autonomous parvovirus that shares up to 80% of sequence homology ...

The synthesis of minus strand by parvovirus LuIII requires replication from the left palindrome of the plus strand DNA. An origin of replication yet to be identified must be present at the right end of the minus strand, ...

Studies to elucidate the mechanism of parvoviral replication are ongoing due to their potential as transient vectors for human gene therapy. Parvovirus LuIII, a single stranded DNA virus, has short double-stranded hairpin ...

There is a continuous search of new implant materials with better biocompatibility and physiological properties than the current commercially pure Ti and Ti-6Al-4V alloys. Gamma titanium aluminide (γTiAl) appears to have ...