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dc.contributor.advisorTorres-Lugo, Madeline
dc.contributor.authorCourt-Pinto, Karem A.
dc.description.abstractParticle encapsulation in polymer systems has been used in several industrial applications in the biomedical and pharmaceutical fields. The main challenge in particle encapsulation is to obtain a homogeneous particle distribution thought the membrane. For the pharmaceutical industry this is a key issue as it is imperative to know how active ingredients in the form of particles are distributed within a therapeutic dose. Current literature lacks information regarding the understanding of the physichochemical interactions of particles distributed in polymeric membranes. Thus, this investigation focuses on the examination of the physicochemical interaction between particles and crosslinked hydrogels networks for the creation of homogenous dispersed membranes. To achieve this objective the effects of particle charge, concentration and size will be examined to ascertain their effect on particle’s dispersion within the matrix. Finally, the effects on the network mechanical properties and rheology will be investigated.
dc.description.abstractLa encapsulación de partículas en polímeros es ampliamente utilizada en biomedicina y en la industria farmacéutica. El reto principal que presenta la industria farmacéutica es obtener membranas con partículas homogéneamente distribuidas. Actualmente la industria farmacéutica está interesada en conocer como se distribuyen las partículas de los ingredientes activos en geles y membranas poliméricas. La literatura científica realizada hasta el momento no reporta un estudio que explique las causas fisicoquímicas que afectan la distribución de partículas en membranas poliméricas. Por tal razón esta investigación consiste en determinar las propiedades fisicoquímicas que afectan la interacción entre partículas e hidrogeles entrecruzados para crear membranas homogéneamente distribuidas. La carga de la partícula, concentración y tamaño y la carga de la membrana serán examinadas como posibles factores que afectan la distribución de partículas en membranas poliméricas. Además, las propiedades mecánicas y reológicas de los hidrogeles serán analizadas.
dc.description.sponsorshipProfessor Carlos Velazquez and ERC-SOPSen_US
dc.subjectParticle encapsulationen_US
dc.subjectCrosslinked hydrogel networksen_US
dc.titleEncapsulation of particles in crosslinked hydrogel networks: particles distribution optimizationen_US
dc.rights.licenseAll rights reserveden_US
dc.rights.holder(c) 2010 Karem Alessandra Court Pintoen_US
dc.contributor.committeeLópez Garriga, Juan
dc.contributor.committeeAcevedo Rullán, Aldo
dc.contributor.committeeOrtiz Bermúdez, Patricia
dc.contributor.representativeRomañach Suarez, Rodolfo Engineeringen_US
dc.contributor.collegeCollege of Engineeringen_US
dc.contributor.departmentDepartment of Chemical Engineeringen_US

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    Items included under this collection are theses, dissertations, and project reports submitted as a requirement for completing a graduate degree at UPR-Mayagüez.

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