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dc.contributor.advisorDiffoot-Carlo, Nanette
dc.contributor.authorRivera-Denizard, Omayra
dc.description.abstractThere is a continuous search of new implant materials with better biocompatibility and physiological properties than the current commercially pure Ti and Ti-6Al-4V alloys. Gamma titanium aluminide (γTiAl) appears to have excellent potential for bone repair and replacement. The response to γTiAl implant is expected to be similar or better than those of Ti-6Al-4V. Human fetal osteoblast cells were cultured on the surface of γTiAl and Ti-6Al-4V discs with variable surface roughness for both SEM and immunofluorescent analysis to detect the presence of collagen type I and osteonectin, proteins of the bone extracellular matrix. Results show that cell growth and attachment on γTiAl was normal compared to that of Ti-6Al-4V, suggesting that γTiAl is not toxic to osteoblasts. Normal growth and the presence of collagen type I and osteonectin was observed on γTiAl and Ti-6Al-4V. The results obtained suggest γTiAl is biocompatible with the osteoblasts.en_US
dc.description.abstractExiste una búsqueda continua de materiales nuevos para ser usados en implantes con mejores propiedades de biocompatibilidad y fisiológicas que los actuales Ti comercialmente puro y aleaciones Ti-6Al-4V. Gamma titanium aluminide (γTiAl), aparenta tener excelente potencial para reparar y reemplazar huesos. Se espera que la respuesta a implantes de γTiAl sea similar o mejor que la de Ti-6Al-4V. Células de osteoblastos fetales humanas fueron cultivadas en la superficie de discos de γTiAl y Ti- 6Al-4V con rugosidades variables para realizarles estudios de MER y análisis de inmunoflorescencia para detectar la presencia de colágeno tipo I y osteonectina, proteínas de la matriz extracelular del hueso. Los resultados muestran que el crecimiento celular y la adhesión en γTiAl eran normales al compararlos con células creciendo en Ti-6Al-4V, sugiriendo que γTiAl no es tóxico para los osteoblastos. El crecimiento normal y la presencia de colágeno tipo I y osteonectina fue observado en células cultivadas en γTiAl y Ti-6Al-4V. Los resultados obtenidos sugieren que γTiAl es biocompatible con los osteoblastos..en_US
dc.subjectImplant materialsen_US
dc.subjectBiocompatibility and physiological propertiesen_US
dc.subjectGamma titanium aluminide (γTiAl)en_US
dc.subjectBone repair and replacementen_US
dc.subject.lcshBone substitutesen_US
dc.titleBiocompatibility studies of human fetal osteoblast cells cultured on gamma titanium alumideen_US
dc.rights.licenseAll rights reserveden_US
dc.rights.holder(c) 2005 Omayra Rivera-Denizarden_US
dc.contributor.committeeNavas, Vivian
dc.contributor.committeeSundaram, Paul A.
dc.contributor.representativeRios, Robert
dc.contributor.collegeCollege of Arts and Sciences - Sciencesen_US
dc.contributor.departmentDepartment of Biologyen_US

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    Items included under this collection are theses, dissertations, and project reports submitted as a requirement for completing a graduate degree at UPR-Mayagüez.

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