Polo-Corrales, Liliana

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    Magnetically and thermally responsive nanoparticles for biomedical applications.
    (2013) Polo-Corrales, Liliana; Rinaldi, Carlos; College of Engineering; Torres Lugo, Madeline; Garcia, Eduardo Juan; Latorre Esteves, Magda; Department of Chemical Engineering; Rivera, Luis A.
    The synthesis of magnetic nanoparticles which respond to alternating magnetic fields by Brownian and Neel relaxation mechanisms are of great interest in determining mechanical properties of complex fluids in the size scale of the nanoparticles and in biomedical applications. Because of their magnetic and thermal properties these particles are attractive in a wide range of applications including magnetic nanoparticle hyperthermia, which consists of destruction of cancer cells and tumors using the heat dissipated by magnetic nanoparticles in Alternating Magnetic Fields (AMFs). In this work, it is demonstrated that the aging of iron-cobalt oleate complex promoted the formation of the spinel crystal structure which influenced the nanoparticle magnetic properties, resulting in an improvement of the magnetic properties. The applications of these magnetic nanoparticles allow the fabrication of nanoscale mechanical probes, which capitalize on the rotational response of the magnetic nanoparticles in an AMF and can be used to determine the nanoscale mechanical properties of a fluid. In other applications, magnetic nanoparticles rotate or dissipate heat when acted upon by an alternating magnetic field (AMF). When coated with a thermoresponsive fluorescent polymer these can report changes in the local temperature. An important gap in this field is monitoring the local thermal effects at the magnetic nanoparticle surface under an alternating magnetic field (AMF). Theory indicates there should not been higher temperature on the surface, but studies indicate that the heat dissipation of magnetic nanoparticles with Neel relaxation, affect the local environment surroundings.