Organic/inorganic films for biosensor application

dc.contributor.advisor Singh, Surinder P. Palomera-Arias, Netzahualcóyotl College of Engineering en_US
dc.contributor.committee Banerjee, Jay E.
dc.contributor.committee Ramírez-Vick, Jaime E.
dc.contributor.department Department of Mechanical Engineering en_US
dc.contributor.representative López-Moreno, Martha 2018-11-10T13:24:33Z 2018-11-10T13:24:33Z 2011
dc.description.abstract Biosensors are becoming increasingly important as practical tools in pathogen detection and molecular diagnostics. Electrochemical biosensors are of particular interest due to several advantages including low-cost, easy operation, and small size. During the development of efficient biosensors, a crucial part is the choice of material onto which a biomolecule has to be immobilized while providing good electron transfer rate at the electrode as a result of a biochemical reaction. Present work deals with the development of novel nanostructured metal oxides and conducting polymer nanocomposites as promising material matrix for biomolecule immobilization, because of their high surface to volume ratio and efficient electron transport properties. We have synthesized ferrocene-polypyrrole based nanocomposites with excellent mechanical and electronic properties. The optimized nanocomposite films have been used for glucose biosensor. Results indicate the good performance of the electropolymerized copolymer of pyrrole and ferrocenecarboxylate modified pyrrole P(Py-FcPy) on indium-tin-oxide (ITO) coated glass for glucose biosensor. On the other hand an inorganic material structure, ZnO nanorods (ZnONR), has been grown on indium tin oxide (ITO) films on glass. This could easily be upgraded with existing MEMS technology to fabricate miniaturized biosensors. Urease (Urs) enzyme was physically immobilized on nanorods exploiting high isoelectric point of ZnO to fabricate Urs/ZnONR/ITO bioelectrode. Urs/ZnONR/ITO bioelectrode revealed a very high sensitivity of 10 µAdL/mg (1.66 µA/mM) in a urea concentration range of 10-25 mg/dl with enhanced linearity. en_US
dc.description.graduationSemester Fall en_US
dc.description.graduationYear 2011 en_US
dc.description.sponsorship IFN-NSF-EPSCoRE start up grant OIA-0701525 and Dean College of Engineering en_US
dc.language.iso en en_US
dc.rights.holder (c) 2011 Netzahualcóyotl Palomera-Arias en_US
dc.rights.license All rights reserved en_US
dc.subject biosensors en_US
dc.subject.lcsh Biosensors. en_US
dc.subject.lcsh Nanocomposites (Materials) en_US
dc.title Organic/inorganic films for biosensor application en_US
dc.type Thesis en_US
dspace.entity.type Publication Mechanical Engineering en_US M.S. en_US
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